Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses E Zervoudi, E Saridakis, JR Birtley, SS Seregin, E Reeves, P Kokkala, ... Proceedings of the National Academy of Sciences 110 (49), 19890-19895, 2013 | 125 | 2013 |
Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy SS Seregin, DM Appledorn, AJ McBride, NJ Schuldt, YA Aldhamen, ... Molecular Therapy 17 (4), 685-696, 2009 | 111 | 2009 |
HIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-γ-inducible protein 10 levels compared with nonusing HIV patients MD Rizzo, RB Crawford, JE Henriquez, YA Aldhamen, P Gulick, ... Aids 32 (4), 419-429, 2018 | 73 | 2018 |
Sublingual administration of an adenovirus serotype 5 (Ad5)-based vaccine confirms Toll-like receptor agonist activity in the oral cavity and elicits improved mucosal and … DM Appledorn, YA Aldhamen, S Godbehere, SS Seregin, A Amalfitano Clinical and Vaccine Immunology 18 (1), 150-160, 2011 | 57 | 2011 |
SLAMF7 signaling reprograms T cells toward exhaustion in the tumor microenvironment P O’Connell, S Hyslop, MK Blake, S Godbehere, A Amalfitano, ... The Journal of Immunology 206 (1), 193-205, 2021 | 48 | 2021 |
Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells YA Aldhamen, Y Pepelyayeva, DPW Rastall, SS Seregin, E Zervoudi, ... Journal of innate immunity 7 (3), 275-289, 2015 | 48 | 2015 |
Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector–triggered immune responses in vitro and in vivo SS Seregin, YA Aldhamen, DM Appledorn, ZC Hartman, NJ Schuldt, ... Blood, The Journal of the American Society of Hematology 116 (10), 1669-1677, 2010 | 45 | 2010 |
A New Adenovirus Based Vaccine Vector Expressing an Eimeria tenella Derived TLR Agonist Improves Cellular Immune Responses to an Antigenic Target DM Appledorn, YA Aldhamen, W DePas, SS Seregin, CJJ Liu, N Schuldt, ... PLoS One 5 (3), e9579, 2010 | 42 | 2010 |
Expression of the SLAM family of receptors adapter EAT-2 as a novel strategy for enhancing beneficial immune responses to vaccine antigens YA Aldhamen, DM Appledorn, SS Seregin, CJ Liu, NJ Schuldt, ... The Journal of Immunology 186 (2), 722-732, 2011 | 41 | 2011 |
Adenovirus-based vaccination against Clostridium difficile toxin A allows for rapid humoral immunity and complete protection from toxin A lethal challenge in mice SS Seregin, YA Aldhamen, DPW Rastall, S Godbehere, A Amalfitano Vaccine 30 (8), 1492-1501, 2012 | 40 | 2012 |
Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune response YA Aldhamen, SS Seregin, DPW Rastall, CF Aylsworth, Y Pepelyayeva, ... PloS one 8 (7), e69539, 2013 | 38 | 2013 |
Systemic innate and adaptive immune responses to SARS-CoV-2 as it relates to other coronaviruses P O’Connell, YA Aldhamen Human Vaccines & Immunotherapeutics 16 (12), 2980-2991, 2020 | 35 | 2020 |
SLAMF7 is a critical negative regulator of IFN-α–Mediated CXCL10 production in chronic HIV infection P O’Connell, Y Pepelyayeva, MK Blake, S Hyslop, RB Crawford, ... The Journal of Immunology 202 (1), 228-238, 2019 | 35 | 2019 |
ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis Y Pepelyayeva, DPW Rastall, YA Aldhamen, P O’Connell, S Raehtz, ... Scientific reports 8 (1), 12464, 2018 | 29 | 2018 |
Immune recognition of gene transfer vectors: focus on adenovirus as a paradigm YA Aldhamen, SS Seregin, A Amalfitano Frontiers in immunology 2, 40, 2011 | 28 | 2011 |
Long-term, high-level hepatic secretion of acid α-glucosidase for Pompe disease achieved in non-human primates using helper-dependent adenovirus DPW Rastall, SS Seregin, YA Aldhamen, LM Kaiser, C Mullins, A Liou, ... Gene Therapy 23 (10), 743-752, 2016 | 24 | 2016 |
CR1/2 is an important suppressor of Adenovirus-induced innate immune responses and is required for induction of neutralizing antibodies SS Seregin, YA Aldhamen, DM Appledorn, NJ Schuldt, AJ McBride, ... Gene therapy 16 (10), 1245-1259, 2009 | 24 | 2009 |
ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory … DPW Rastall, YA Aldhamen, SS Seregin, S Godbehere, A Amalfitano International immunology 26 (12), 685-695, 2014 | 23 | 2014 |
Manipulation of EAT-2 expression promotes induction of multiple beneficial regulatory and effector functions of the human innate immune system as a novel immunomodulatory strategy YA Aldhamen, SS Seregin, CF Aylsworth, S Godbehere, A Amalfitano International immunology 26 (5), 291-303, 2014 | 21 | 2014 |
TRIF is a critical negative regulator of TLR agonist mediated activation of dendritic cells in vivo SS Seregin, YA Aldhamen, DM Appledorn, CF Aylsworth, S Godbehere, ... PloS one 6 (7), e22064, 2011 | 21 | 2011 |