| A consensus genome-scale reconstruction of Chinese hamster ovary cell metabolism H Hefzi, KS Ang, M Hanscho, A Bordbar, D Ruckerbauer, M Lakshmanan, ... Cell systems 3 (5), 434-443. e8, 2016 | 238 | 2016 |
| Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion JM Gutierrez, A Feizi, S Li, TB Kallehauge, H Hefzi, LM Grav, D Ley, ... Nature communications 11 (1), 68, 2020 | 105 | 2020 |
| Multiplex secretome engineering enhances recombinant protein production and purity S Kol, D Ley, T Wulff, M Decker, J Arnsdorf, S Schoffelen, AH Hansen, ... Nature communications 11 (1), 1908, 2020 | 87 | 2020 |
| Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion TB Kallehauge, S Li, LE Pedersen, TK Ha, D Ley, MR Andersen, ... Scientific reports 7 (1), 40388, 2017 | 61 | 2017 |
| Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion D Ley, S Pereira, LE Pedersen, J Arnsdorf, H Hefzi, AM Davy, TK Ha, ... Metabolic engineering 56, 120-129, 2019 | 31 | 2019 |
| Multi‐omic profiling of EPO‐producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production D Ley, AK Seresht, M Engmark, O Magdenoska, KF Nielsen, ... Biotechnology and Bioengineering 112 (11), 2373-2387, 2015 | 24 | 2015 |
| Fed-batch CHO cell culture for lab-scale antibody production Y Fan, D Ley, MR Andersen Recombinant Glycoprotein Production: Methods and Protocols, 147-161, 2018 | 23 | 2018 |
| BCAT1 and BCAT2 disruption in CHO cells has cell line-dependent effects S Pereira, D Ley, M Schubert, LM Grav, HF Kildegaard, MR Andersen Journal of biotechnology 306, 24-31, 2019 | 7 | 2019 |
| A Consensus genomescale reconstruction of Chinese hamster ovary cell metabolism. Cell Syst 3 (5): 434-443. e8 H Hefzi, KS Ang, M Hanscho, A Bordbar, D Ruckerbauer, M Lakshmanan, ... | 6 | 2016 |
| A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism. Cell Syst. 3, 434–443 e8 H Hefzi, KS Ang, M Hanscho, A Bordbar, D Ruckerbauer, M Lakshmanan, ... | 6 | 2016 |
| Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion. Nat Commun. 11, 68 JM Gutierrez, A Feizi, S Li, TB Kallehauge, H Hefzi, LM Grav, D Ley, ... Nucleic Acids Res 46 (D1), D656-D660, 2020 | 5 | 2020 |
| Multiplex secretome engineering enhances recombinant protein production and purity. Nat Commun 11 (1): 1908 S Kol, D Ley, T Wulff, M Decker, J Arnsdorf, S Schoffelen, AH Hansen, ... | 4 | 2020 |
| Method for reducing ammonium and lactate production in CHO cells LEY Daniel, MR Andersen, HF Kildegaard US Patent 10,961,556, 2021 | | 2021 |
| Efficient S-acylation of thiourea DJ Jones, UBR Khandavilli, EM O’Leary, SE Lawrence, TP O’Sullivan SynOpen 2 (04), 0263-0267, 2018 | | 2018 |
| Multi-omic profiling of EPO-producing CHO cell panel reveals metabolic adaptation to heterologous protein production D Ley, AK Seresht, M Engmark, O Magdenoska, KF Nielsen, ... Cell Culture Engineering XV, 2016 | | 2016 |
| Engineering amino acid supply pathways in Chinese hamster ovary cells D Ley, AM Lund, J Rank, HF Kildegaard, MR Andersen 9th Danish Conference on Biotechnology and Molecular Biology: Symposium on …, 2014 | | 2014 |
| A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism M Lakshmanan, CA Orellana, D Baycin-Hizal, Y Huang, D Ley, ... | | |
| Multi-omic profiling of EPO-producing CHO cell panel reveals metabolic adaptation to heterologous protein production-DTU Orbit (30/12/2018) D Ley | | |
| Development of CHO cell factories using metabolic network reconstruction, omics data integration and CRISPR/Cas9 genome editing D Ley, AM Lund, SP Bjørn, LE Pedersen, HF Kildegaard, MR Andersen | | |
Helene Faustrup KildegaardNovo NordiskVerified email at faustrup.dk
