Παρακολούθηση
Demetres Leonidas
Demetres Leonidas
Professor of Biochemistry, Department of Biochemistry and Biotechnology, University of Thessaly
Η διεύθυνση ηλεκτρονικού ταχυδρομείου έχει επαληθευτεί στον τομέα bio.uth.gr - Αρχική σελίδα
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Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure− activity relationships, and X-ray crystallographic studies
X Wen, H Sun, J Liu, K Cheng, P Zhang, L Zhang, J Hao, L Zhang, P Ni, ...
Journal of Medicinal Chemistry 51 (12), 3540-3554, 2008
2432008
New inhibitors of glycogen phosphorylase as potential antidiabetic agents
L Somsák, K Czifrák, M Tóth, E Bokor, ED Chrysina, KM Alexacou, ...
Current medicinal chemistry 15 (28), 2933-2983, 2008
2182008
Glucose analog inhibitors of glycogen phosphorylase: The design of potential drugs for diabetes
JL Martin, K Veluraja, K Ross, LN Johnson, GWJ Fleet, NG Ramsden, ...
Biochemistry 30 (42), 10101-10116, 1991
1751991
The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 Å resolution
S Iyer, DD Leonidas, GJ Swaminathan, D Maglione, M Battisti, M Tucci, ...
Journal of Biological Chemistry 276 (15), 12153-12161, 2001
1632001
Design of Inhibitors of Glycogen Phosphorylase: A Study of. alpha.-and. beta.-C-Glucosides and 1-Thio-. beta.-D-glucose Compounds
KA Watson, EP Mitchell, LN Johnson, CJF Bichard, MG Orchard, ...
Biochemistry 33 (19), 5745-5758, 1994
1621994
Charcot-Leyden crystal protein (galectin-10) is not a dual function galectin with lysophospholipase activity but binds a lysophospholipase inhibitor in a novel structural fashion
SJ Ackerman, L Liu, MA Kwatia, MP Savage, DD Leonidas, ...
Journal of Biological Chemistry 277 (17), 14859-14868, 2002
1542002
Anopheles gambiae odorant binding protein crystal complex with the synthetic repellent DEET: implications for structure-based design of novel mosquito repellents
KE Tsitsanou, T Thireou, CE Drakou, K Koussis, MV Keramioti, ...
Cellular and Molecular Life Sciences 69, 283-297, 2012
1232012
Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in …
DD Leonidas, R Shapiro, SC Allen, GV Subbarao, K Veluraja, ...
Journal of molecular biology 285 (3), 1209-1233, 1999
1201999
Natural products and their derivatives as inhibitors of glycogen phosphorylase: potential treatment for type 2 diabetes
JM Hayes, AL Kantsadi, DD Leonidas
Phytochemistry Reviews 13, 471-498, 2014
1102014
Kinetic and crystallographic studies on 2‐(β‐D‐glucopyranosyl)‐5‐methyl‐1, 3, 4‐oxadiazole,‐benzothiazole, and‐benzimidazole, inhibitors of muscle glycogen phosphorylase b …
ED Chrysina, MN Kosmopoulou, C Tiraidis, R Kardakaris, N Bischler, ...
Protein science 14 (4), 873-888, 2005
1092005
Glucose-based spiro-isoxazolines: A new family of potent glycogen phosphorylase inhibitors
M Benltifa, JM Hayes, S Vidal, D Gueyrard, PG Goekjian, JP Praly, ...
Bioorganic & medicinal chemistry 17 (20), 7368-7380, 2009
992009
Crystal Structure of Eosinophil Cationic Protein at 2.4 Å Resolution,
E Boix, DD Leonidas, Z Nikolovski, MV Nogués, CM Cuchillo, KR Acharya
Biochemistry 38 (51), 16794-16801, 1999
981999
Crystal Structures of Ribonuclease A Complexes with 5‘-Diphosphoadenosine 3‘-Phosphate and 5‘-Diphosphoadenosine 2‘-Phosphate at 1.7 Å Resolution,
DD Leonidas, R Shapiro, LI Irons, N Russo, KR Acharya
Biochemistry 36 (18), 5578-5588, 1997
981997
Binding of N‐acetyl‐N ′‐β‐d‐glucopyranosyl urea and N‐benzoyl‐N ′‐β‐d‐glucopyranosyl urea to glycogen phosphorylase b Kinetic and …
NG Oikonomakos, M Kosmopoulou, SE Zographos, DD Leonidas, ...
European journal of biochemistry 269 (6), 1684-1696, 2002
972002
Amide-1, 2, 3-triazole bioisosterism: the glycogen phosphorylase case
ED Chrysina, É Bokor, KM Alexacou, MD Charavgi, GN Oikonomakos, ...
Tetrahedron: Asymmetry 20 (6-8), 733-740, 2009
932009
Nicotinic cholinergic system and COVID-19: in silico identification of an interaction between SARS-CoV-2 and nicotinic receptors with potential therapeutic targeting implications
K Farsalinos, E Eliopoulos, DD Leonidas, GE Papadopoulos, S Tzartos, ...
International journal of molecular sciences 21 (16), 5807, 2020
912020
Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition
NG Oikonomakos, C Tiraidis, DD Leonidas, SE Zographos, M Kristiansen, ...
Journal of medicinal chemistry 49 (19), 5687-5701, 2006
872006
The binding of β‐and γ‐cyclodextrins to glycogen phosphorylase b: Kinetic and crystallographic studies
N Pinotsis, DD Leonidas, ED Chrysina, NG Oikonomakos, IM Mavridis
Protein science 12 (9), 1914-1924, 2003
802003
High‐resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure‐based design of ribonucleolytic …
DD Leonidas, GB Chavali, NG Oikonomakos, ED Chrysina, ...
Protein Science 12 (11), 2559-2574, 2003
742003
1-(3-Deoxy-3-fluoro-β-D-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies
VG Tsirkone, E Tsoukala, C Lamprakis, S Manta, JM Hayes, VT Skamnaki, ...
Bioorganic & medicinal chemistry 18 (10), 3413-3425, 2010
692010
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